中文名稱：5-脂氧合酶抗體

產(chǎn)品貨號：ZIKER-0526R

英文名稱：ALOX5/5 lipoxygenase
別    名：5-lipoxygenase; 5-LOX; 5 LO; 5LPG; ALOX 5; ALOX5; Arachidonate 5 lipoxygenase; Arachidonic acid 5 lipoxygenase; Leukotriene A4 synthase; LOG 5; LOG5; MGC163204; LOX5_HUMAN. 
規(guī)     格 ：50ul  100ul  200ul
研究領域：腫瘤  免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  合成與降解  
抗體來源：Rabbit
克隆類型：Polyclonal
交叉反應 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應用：WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量：78kDa
細胞定位：細胞核 細胞漿 細胞膜 
性    狀：Lyophilized or Liquid
濃    度：1mg/ml
免 疫 原：KLH conjugated synthetic peptide derived from human 5 Lipoxygenase:601-674/674 
亞    型：IgG
純化方法：affinity purified by Protein A
儲 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹background:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Function:
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Subunit:
Interacts with ALOX5AP and LTC4S.

Subcellular Location:
Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. 

Post-translational modifications:
Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.

Similarity:
Belongs to the lipoxygenase family.
Contains 1 lipoxygenase domain.
Contains 1 PLAT domain.

SWISS:
P48999

Gene ID:
240

Database links:
Entrez Gene: 477753 Dog

Entrez Gene: 240 Human

Entrez Gene: 11689 Mouse

Entrez Gene: 25290 Rat

Omim: 152390 Human

SwissProt: P09917 Human

SwissProt: P48999 Mouse

SwissProt: P12527 Rat

Unigene: 89499 Human

Unigene: 41072 Mouse

Unigene: 9662 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

合成與降解（Synthesis and Degradation）
5-脂氧合酶蛋白是花生四烯酸代謝途徑中的一種關鍵酶，在惡性腫瘤的發(fā)生、發(fā)展過程中起了重要作用。抑制5-脂氧合酶及其產(chǎn)物的表達有可能預防和逆轉(zhuǎn)惡性腫瘤的發(fā)生。